Why Recombinant Vaccines are Gaining Momentum Globally

The global shingles vaccine market is witnessing unprecedented growth, with its market size projected to leap from USD 4.86 billion in 2024 to a staggering USD 12.31 billion by 2032, expanding at a compound annual growth rate (CAGR) of 12.35% over the forecast period of 2025 to 2032. This acceleration is largely attributed to the increasing prevalence of shingles (herpes zoster), particularly among the elderly, as well as widespread integration of shingles vaccines into national immunization programs.

Rising Prevalence and Government Intervention: The Twin Growth Catalysts

Shingles, caused by the reactivation of the varicella-zoster virus (VZV), typically affects older adults or individuals with weakened immune systems. As global demographics tilt toward an aging population, the incidence of shingles is rising sharply. According to health authorities, approximately 1 in 3 people will develop shingles in their lifetime, with higher rates in those aged 50 and older.

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This trend is propelling demand for preventive healthcare, especially vaccines. Governments around the world are now recognizing the public health and economic burden of shingles. Consequently, national immunization campaigns have increasingly included shingles vaccines—especially in high-income and aging countries like the U.S., Canada, Germany, Japan, and Australia.

Market Segmentation: Diverse Products and Vaccine Types Fuel Innovation

The shingles vaccine market is segmented by product and vaccine type. The three dominant product categories are:

• Shingrix (GlaxoSmithKline): A recombinant, non-live vaccine recommended for individuals aged 50 and older.
• SKYZoster (SK bioscience): A live attenuated vaccine approved in select regions.
• Zostavax (Merck & Co., Inc.): One of the earlier shingles vaccines, still in circulation despite being largely replaced by Shingrix in developed countries.

By vaccine type, the market is split into:

• Live Attenuated Vaccines: These vaccines contain a weakened form of the virus and have shown moderate efficacy but are less recommended for immunocompromised individuals.
• Recombinant Vaccines: More advanced, offering stronger immunity and safety profiles. This segment is expected to dominate the market in the coming years.

Regional Breakdown: North America Leads, Asia-Pacific Emerges

North America, particularly the United States, currently dominates the shingles vaccine market due to high vaccine awareness, strong healthcare infrastructure, and active support from agencies like the Centers for Disease Control and Prevention (CDC). Reimbursement policies and government-backed vaccination programs have also propelled uptake.

Europe follows closely, with countries like Germany, France, and the United Kingdom integrating shingles vaccines into public health agendas. Meanwhile, Asia-Pacific is emerging as a high-growth region, driven by rising geriatric populations in Japan, China, and India, along with increased government investment in immunization.

Other regions such as Latin America and the Middle East & Africa show slower uptake but present untapped opportunities due to improving healthcare access and increasing public awareness.

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Competitive Landscape: Innovation and Expansion Drive Market Dynamics

The shingles vaccine market features a mix of pharmaceutical giants and emerging biotech firms. Key players include:

• GlaxoSmithKline (GSK): Dominates with Shingrix, considered the gold standard in shingles prevention.
• Merck & Co., Inc.: Maker of Zostavax, continues to contribute significantly despite shifting market dynamics.
• Vaccitech, Pfizer Inc., BioNTech SE, and GeneOne Life Science: Actively developing next-gen shingles vaccines using mRNA and recombinant technologies.
• SK bioscience, Curevo Inc., and Jiangsu Recbio Technology Co., Ltd.: Gaining traction in regional markets.

Collaborations, acquisitions, and technological innovation—especially around mRNA vaccine platforms—are set to transform the shingles vaccine development pipeline and widen access globally.

Future Outlook: Emphasis on Elderly Wellness and Vaccine Access

Looking forward, the shingles vaccine market is expected to benefit from:

• Ongoing demographic shifts, with more individuals over 60 years of age globally.
• Enhanced vaccine education and public-private partnerships.
• Expansion of cold chain logistics and distribution in emerging economies.
• Breakthroughs in vaccine technology, especially in the wake of COVID-19 innovations.

Challenges such as vaccine hesitancy, high production costs, and limited access in low-income countries remain, but are gradually being addressed through global health initiatives and industry partnerships.

Conclusion

The shingles vaccine market stands at a pivotal juncture. As public health systems shift focus toward preventive care for aging populations, and vaccine science continues to evolve, the market is poised for robust growth. Key industry stakeholders, from multinational pharma companies to healthcare policymakers, must now collaborate to ensure equitable access, affordability, and awareness—making shingles vaccination a standard part of global immunization frameworks.