How to Fix SMTP Email Error 421 When Sending Messages from Your Server

When managing an email server or sending bulk messages from a website or application, encountering SMTP Email Error 421 can be frustrating and disruptive.

When managing an email server or sending bulk messages from a website or application, encountering SMTP Email Error 421 can be frustrating and disruptive. This error indicates that the server is currently unavailable or is temporarily rejecting the connection. While it’s typically a temporary issue, persistent 421 errors can delay communications and affect business operations.

What Is SMTP Email Error 421?

The SMTP Email Error 421 is a temporary response code from the recipient’s mail server, signaling that it cannot process your request at the moment. It usually appears in the following format

Common Variations of SMTP Error 421

Although the core meaning is the same, different email service providers may display SMTP Error 421 in slightly varied formats. Some common examples include:

  • 421 Too many connections, try again later
  • 421 Temporary failure, please try again later
  • 421 Service not available – closing transmission channel
  • 421 4.7.0 [TSS04] Messages from [IP Address] temporarily deferred

These messages can provide insight into the root cause—whether it’s a server capacity issue, rate-limiting policy, DNS misconfiguration, or security block.

Primary Causes of SMTP Email Error 421

Understanding the root cause is the first step to resolving the issue. Here are the most common reasons why SMTP Error 421 might occur:

1. Mail Server Overload

If the recipient mail server is under heavy load, it may respond with a 421 error to defer processing until its queue is cleared.

2. IP Reputation or Blacklisting

If your server’s IP has a poor reputation due to spam complaints or misuse, the recipient server might temporarily defer your messages.

3. Too Many Concurrent SMTP Connections

Most mail servers limit the number of simultaneous connections from a single IP. Exceeding this can lead to temporary rejection.

4. DNS Resolution Issues

Incorrect or slow DNS lookups during email routing may result in the server returning a 421 error.

5. SMTP Rate-Limiting Policies

Some mail servers enforce throttling policies if you send too many emails in a short time.

6. Misconfigured Reverse DNS (PTR Records)

Missing or incorrect reverse DNS entries can trigger temporary rejections with 421 responses.

7. Temporary Network or Hardware Failures

In some cases, the error might originate from server crashes, timeouts, or resource shortages.

How to Troubleshoot and Fix SMTP Email Error 421

Fixing SMTP Email Error 421 requires a systematic approach to rule out server-side misconfigurations, networking issues, or reputation problems. Here are actionable steps:

Monitor and Reduce Email Sending Volume

If you’re sending bulk emails or automated messages, reduce the rate at which messages are sent. Add throttling or batching logic to limit the number of connections per minute.

For example:

  • Limit connections to 10–20 per minute
  • Pause between email batches
  • Spread out campaigns over a longer period

This is especially important when emailing large providers like Gmail, Yahoo, or Comcast.

3. Scan and Improve IP Reputation

Use tools such as:

  • SenderScore
  • MXToolbox Blacklist Check
  • Talos Intelligence

If your IP is blacklisted or has a poor sender score, follow the provider's delisting process and adjust your sending practices to avoid future blocks.

4. Configure SPF, DKIM, and DMARC Records

Lack of proper authentication records can result in temporary rejections.

Ensure your domain has:

  • SPF record allowing your IP to send emails
  • DKIM signatures for verifying content integrity
  • DMARC policies to instruct recipient servers on how to handle spoofed emails

Review and Correct PTR (Reverse DNS) Records

Ensure that your IP address resolves back to your domain. A mismatch between your forward and reverse DNS records can trigger rejection or deferment.

 

8. Contact the Recipient's Postmaster or Email Administrator

If the 421 error persists and targets specific domains (e.g., Gmail or Comcast), reach out to their postmaster. Explain the situation, show logs, and request guidance or whitelisting.

Common postmaster contact portals:

  • Comcast: https:// postmaster. comcast. net
  • Microsoft: https:/ /sender .office. com

How to Prevent SMTP Email Error 421 in the Future

After resolving the immediate issue, take steps to ensure it doesn’t recur.

Set Up Proper Throttling Rules

Use email software (e.g., Postfix, Exim, Mailgun, or Amazon SES) with rate-limiting capabilities. Schedule messages in manageable intervals, especially for large mailing lists.

Maintain a Clean Mailing List

Remove invalid or inactive addresses regularly. Repeatedly sending to non-existent recipients increases your bounce rate and lowers your reputation.

Implement Feedback Loops

Sign up for feedback loops (FBL) offered by major ISPs to receive spam complaints. This helps you monitor user feedback and stop emailing people who mark your content as spam.

Recommended to read: How to Fix SMTP Email Error 500 5.7.1?

Use a Reputable SMTP Relay Provider

If you're on a shared hosting environment or using a VPS with no reputation history, consider using a trusted SMTP provider like:

  • SendGrid
  • Mailgun
  • Amazon SES
  • SMTP2GO

These services handle delivery, DNS compliance, rate limits, and monitoring for you.

Monitor Email Deliverability Metrics

Track bounce rates, open rates, complaints, and block lists using tools or platforms with reporting dashboards. This helps catch problems early before they escalate into widespread issues.

Conclusion

SMTP Email Error 421 is a temporary but significant barrier to smooth email communication. While it’s often caused by server overloads, rate limiting, or IP reputation issues, persistent 421 errors require immediate attention to maintain reliable email delivery.

By analyzing your mail logs, optimizing your email volume, ensuring DNS and authentication records are correctly configured, and using industry best practices, you can fix the problem and avoid future setbacks.