In the Franchise mode of Madden NFL 22, players can take on the role of a team's owner, coach, or player to manage their team's season. The mode includes various features such as staff hiring and firing, player contracts and negotiations, scouting, drafting, and game planning. Additionally, the mode includes a new feature called "Weekly Strategy," which allows players to plan their team's gameplay and adjust their strategy based on their opponent's strengths and weaknesses.